If you encountered the following error during sending an outgoing email from e2a email client, it might have been caused due to deliverability access permissions. Please follow the steps below to resolve this issue.

To configure the email deliverability settings for your organization:
Note: By Default all new Production environment's Access level is set to 'All email'. However newly created Sandboxes have Access Level set to 'System email only' and need to be set to 'All email' in order to make it work and allow e2a to send outbound emails.
For more details on deliverability, please see https://help.salesforce.com/HTViewHelpDoc?id=emailadmin_deliverability.htm
Please contact us at support@ortooapps.com for any questions.